PRINTO past project details
Core set of outcome measures and definition of improvement for juvenile arthritis
The first of PRINTO’s achieved goals was to define a core set of outcome measures and a definition of improvement to be used in clinical trials in children with juvenile arthritis (JA). This project was developed under the leadership of the US-based Pediatric Rheumatology Collaborative Study Group (PRCSG). Following publication of the definition of improvement (Giannini EH, Ruperto N, et al) it was subsequently adopted by the US Food and Drug Administration (FDA) as primary outcome for all clinical trials involving children with JIA and recently also by the European Medicines Agency (EMEA). This definition is now officially recognized as American College of Rheumatology (ACR) paediatric 30 definition of improvement
Consolaro A, Ruperto N, Bracciolini G, Frisina A, Gallo MC, Pistorio A, Verazza S, Negro G, Gerloni V, Goldenstein-Schainberg C, Sztajnbok F, Wulffraat NM, Martini A, Ravelli A for the Paediatric Rheumatology International Trials Organization (PRINTO)Defining criteria for high disease activity in juvenile idiopathic arthritis based on the Juvenile Arthritis Disease Activity Score
Ann Rheum Dis 2014;73(7):1380-3
Consolaro A, Negro G, Gallo MC, Bracciolini G, Ferrari C, Schiappapietra B, Pistorio A, Bovis F, Ruperto N, Martini A, Ravelli A.Defining criteria for disease activity States in nonsystemic juvenile idiopathic arthritis based on a three-variable juvenile arthritis disease activity score.
Arthritis Care Res 2014;66(11):1703-9
Wallace CA, Giannini EH, Huang B, Itert L, Ruperto N for the Childhood Arthritis and Rheumatology Research Alliance (CARRA); the Pediatric Rheumatology Collaborative Study Group (PRCSG) and the Pediatric Rheumatology InterNational Trials Organisation (PRINTO).American College of Rheumatology provisional criteria for defining clinically inactive disease in select categories of juvenile idiopathic arthritis.
Arthritis Care Res 2011;63;929-936
Consolaro A, Ruperto N, Bazso A, Pistorio A, Magni-Manzoni S, Filocamo G, Malattia C, Viola S, Martini A, Ravelli A, for the Pediatric Rheumatology International Trials Organisation (PRINTO).Development and validation of a composite disease activity score for juvenile idiopathic arthritis.
Arthritis Rheum 2009;61(5):658-66
Giannini EH, Ruperto N, Ravelli A, Lovell DJ, Felson DT, Martini A for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and the Paediatric Rheumatology International Trials Organisation (PRINTO).Preliminary definition of improvement in juvenile arthritis.
Arthritis Rheum 1997; 40: 1202-1209